The single image shows the take-home message of the study “Adult Conditional Knockout of PGC-1alpha Leads to Loss of Dopamine Neurons” http://eneuro.org/content/3/4/ENEURO.0183-16.2016. The study found that the loss of the protein PGC-1alpha is sufficient to result in the loss of dopaminergic neurons in mice. The highlighted blue area on the upper left shows the dopaminergic (DA) neurons and their projections in wild-type mouse model; the blue dotted line area on the upper right shows the much reduced dopaminergic neurons in PGC-1alpha knockout mouse model.
- Media: Adobe Photoshop, Illustrator CC
- Intended Audience: Neurologists, basic scientists, graduate students